How Sleep Deprivation Accelerates Skin Ageing

These processes are guided by our circadian rhythm, the body’s internal clock that helps regulate biological activity across day and night. When this rhythm is disrupted, the skin’s ability to renew itself may be affected, potentially leading to dehydration, delayed recovery, or early signs of ageing.

Understanding the connection between sleep and skin ageing, and what happens to the skin while sleeping can help you make more informed choices—both in your sleep routine and in the formulations you choose to support overnight skin repair.

More to consider: 

Sleep is often considered a time of rest, but for the skin, it is a period of heightened activity. As the body shifts into repair mode, the skin begins to carry out essential processes that help restore balance, strengthen its defences, and respond to the demands of the da

During this overnight cycle, the following processes become more active:

• Collagen synthesis: Growth hormones which are primarily released during sleep, stimulate collagen production, which contributes to skin structure, firmness, and barrier integrity. Similarly, ingredients like copper peptides have also been shown to boost collagen synthesis by triggering some of the same processes as growth hormones.
  
  
• Barrier recovery: The skin barrier experiences increased cell turnover and repair during sleep. This helps to rebuild the lipid matrix which is made up of ceramides and other fatty acids, to restore moisture levels and protect against transepidermal water loss.
  
  
• Cellular repair and turnover: The repair and renewal of skin cells damaged by daily exposure from UV radiation and pollution, increases during sleep. Part of this process includes DNA repair and increased cell turnover. As damaged and dead skin cells are replaced, skin texture and tone will gradually improve.
  
  
• Oxidative stress response: Antioxidant pathways are more active during sleep, helping the skin recover from environmental stressors such as pollution and UV exposure.
  
  
• Enhanced microcirculation: Blood flow to the skin increases, delivering oxygen and nutrients that support cellular activity and regeneration.
  
  
• Increased permeability: The skin becomes more receptive to topical ingredients, making nighttime an optimal window for applying targeted treatments.

To support these natural overnight repair and regeneration processes, it’s essential to maintain consistent, high-quality sleep. Experts recommend 7-9 hours of sleep per night to ensure these processes are optimised.

Several studies have explored the impact of sleep deprivation on overall health, as well as the relationship between sleep and skin ageing. This research suggests that sleep deprivation effects on skin include accelerating visible signs of skin ageing, including wrinkles and dullness, due to disrupted cellular repair processes and reduced collagen production.

These are common skin concerns that are exacerbated by sleep deprivation:

Fine lines and loss of elasticity

Dull dehydrated skin

Poor sleep weakens the skin barrier, reducing its ability to retain moisture and protect against external stressors. This weakened barrier leads to increased transepidermal water loss (TEWL), resulting in dehydration, dryness, and lackluster skin.

Puffiness & dark circles

The connection between dark circles and sleep is well-established. When the sleep cycle is interrupted, blood circulation is impaired. This reduces blood flow and causes fluid retention in the face and eyes causing puffiness and pooling of blood under the eyes resulting in a darkened appearance commonly known as eye bags or dark circles.

NIOD’s science-led approach to skin repair works with skin’s natural processes to enhance and strengthen overnight skin regeneration. Explore some of our skin optimising formulations:

Copper Amino Isolate Lipid 1% (CAIL)

Copper peptides support skin regeneration by stimulating collagen and elastin production, mirroring some of the natural reparative processes that take place during sleep. However, if sleep is insufficient, these processes can slow down, weakening the skin’s natural ability to repair itself, highlighting the connection between collagen and sleep. Incorporating copper peptides into your PM skincare regimen can help counteract this decline by reinforcing collagen and elastin synthesis—promoting firmer, healthier-looking skin.

We recommend using Copper Amino Isolate Lipid 1%, our patented plumping nighttime gel engineered to improve volume and hydration as skin ages. CAIL’s patented delivery system penetrates the skin’s protective barrier for enhanced delivery of the active Copper Peptide ingredient. This method increases volume via hydration, addressing skin thinning over time for improved structural integrity.

Fractionated Eye Contour Concentrate (FECC)

As highlighted earlier, poor-quality sleep impairs blood circulation causing fluid retention which contributes to puffiness and dark circles around the eye area. Our Fractionated Eye Contour Concentrate counteracts these effects with 28 active technologies and utilises drone-like technology to precisely target and deliver key active ingredients to address visible signs of ageing around the eye area such as fine lines, wrinkles, puffiness, and dark circles.

Voicemail Masque (VM)

To support overnight regeneration, we recommend Voicemail Masque—a concentrated leave-on treatment formulated for nighttime use. This formulation contains postbiotic compounds, which are produced through the probiotics’ fermentation process. This group of compounds support skin health by promoting a balanced skin microbiome and enhancing the skin’s natural defenses.

It also contains plant stem cell extracts, including Plantago lanceolata leaf extract, which helps improve the feel of skin firmness and density while visibly reducing the appearance of age spots. Another key ingredient is Leontopodium alpinum callus culture extract, a technology that targets the look of wrinkles around the eyes and contributes to a visibly lifted appearance in areas prone to sagging, such as the face and neck.

Sleep and skin ageing are intrinsically linked, therefore prioritizing sufficient, quality sleep is key to maximizing skin repair and regeneration. Consistent, restorative sleep supports the skin's natural regenerative processes, including collagen synthesis and cellular repair. To support this, implementing a consistent evening routine could be beneficial:

• Set a sleep schedule: adhere to a regular sleep-wake cycle, even on weekends, to help regulate the body’s circadian rhythm, which helps to optimise sleep quality

• Avoid screentime before bed: reducing exposure to blue light emitted by screens at least 30 to 60 minutes prior to sleep supports melatonin production, enhancing the body’s natural sleep cycle. Common sources of blue light include smartphones, TVs, computer or tablet screens, or LED lights.

• Establish a relaxing nighttime routine: engaging in calming activities, such as reading or mindfulness exercises, can promote the transition into the sleep phase by activating the parasympathetic nervous system. This part of the nervous system promotes relaxation, energy conservation, and bodily functions like digestion and heart rate regulation.

• Optimise the sleep environment: A sleep-conducive environment, characterized by low ambient light, cool temperatures, and minimal noise, promotes deeper and more restorative sleep.

• Adopt a nighttime skincare regimen: Maximize the benefits of your skin care products by using them in your PM skincare routine when skin repair and regeneration processes are at their peak.

While achieving a full night’s rest plays an important role in overall well-being, the demands of daily life can make it challenging. Prioritising quality sleep supports the body’s ability to repair, restore, and regulate key functions—many of which are linked to skin health. Alongside NIOD’s advanced skincare interventions, consistent and restorative sleep can help maintain the look and function of healthy skin over time.

NIOD’s targeted formulations work alongside the skin’s natural rhythms to help reduce the visible effects of poor sleep. Copper Amino Isolate Lipid 1% supports overnight regeneration and collagen production, Fractionated Eye Contour Concentrate targets puffiness and dark circles, and Voicemail Masque helps improve radiance, texture, and overall signs of skin fatigue.

Supporting the skin begins with understanding its rhythms. By aligning rest with science-led care, it becomes possible to preserve the visible integrity, clarity, and resilience of skin—long after the lights go out. Explore products for overnight skin repair